Jon Pace writes in the comments section that we should start to look at those actors who could use a comeback a la Mickey Rourke about now. He suggests:
3. Ally Sheedy – She got nice reviews in High Art, 10+ years ago. Was never a bad actress, still looks great, and think if she got a decent supporting role directed by a talented Aronofsky-type director she would do wonders.
2. Kathleen Turner РShe has not aged particularly well and I think had a reputation for being difficult, but my goodness when I go over her filmography she made some great films in the 80’s Рat least extremely entertaining roles. I think if a director could cast her in a dramatic supporting role she could be wonderful. Would like to see it.
1. Rick Moranis – He left the film industry to raise his kids after his wife died. He has expressed a desire not to go back to films and live a quiet life in NYC. However I think if a Sofia Coppola/Alexander Payne-type director wrote a supporting role that was mainly dramatic with bits of comedy in it he could snatch an Oscar nomination. Would love to see him comeback.
Rick Moranis is interesting. There are two directors who use actors well in this regard – 
Quentin Tarantino (has made it into an art form) and Christopher Guest. Mickey Rourke suggested indie actors giving Eric Roberts the role of a lifetime. No one has yet or if they have, nothing has come of it. Off the top of my head, actors I think deserve a decent break: Debra Winger is someone I’d love to see with a juicy lead role that really challenges her abilities.¬† I’d like to see Helen Hunt come back to see if the Oscar was a fluke or not. And likewise, Haley Joel Osment could be used interestingly.¬† And finally, Kevin Spacey could probably use some sort of career intervention. Pay if Forward 2?
